On Oct 6-8 we will be attending both CPHI in Milan and CRN Annual Signature Event in Carlsbad, California. Hope to meet you there!
Probi’s flagship Lactiplantibacillus plantarum 299v (LP299V®) was originally isolated from healthy human intestinal mucosa by Prof Dr Bengt Jeppsson at Lund University in Sweden.
LP299V has been studied extensively for more than three decades with a substantial body of vitro, animal, and human clinical research. This makes it one of the most scientifically validated probiotics and the most clinically documented L.plantarum strains available.
For nutraceutical brands, supplement manufacturers and functional food and beverage developers, LP299V offers a clinically documented probiotic ingredient with extensive scientific heritage, proven gastrointestinal survival, strong formulation flexibility and global technical support from Probi. As a leading L. plantarum probiotic, LP299V provides formulators with a scientifically substantiated solution backed by decades of research.
For more than 35 years, LP299V® has remained at the forefront of probiotic and microbiome research.
85+ human clinical studies
Investigated across a broad range of populations, health outcomes, and commercial applications.
300+ scientific publications
Supported by decades of peer-reviewed scientific research and ongoing microbiome probiotics investigation.
35+ years of research
Developed from pioneering probiotic research originating at Lund University in Sweden.
Clinically documented mechanisms
Extensively studied gastrointestinal survival, intestinal adhesion, and microbiome interaction.
Survival in the gastrointestinal tract
Demonstrated ability to survive digestive transit and to remain detectable after supplementation.
Global commercial success
Trusted by formulators and brands seeking clinically tested probiotics, backed by science.
LP299V is a clinically researched probiotic strain that adheres to the lining of the gut, enabling it to interact directly with the intestinal cells and overall environment. This interaction helps support digestive health, strengthen the gut barrier, and promote a balanced microbiome.
LP299V possesses a unique adhesion mechanism that allows it to bind to mannose receptors on intestinal epithelial cells. This close attachment is considered a key factor behind many of its observed benefits and distinguishes it from many other probiotic strains.
Clinical studies have demonstrated that LP299V survives the challenging conditions of the gastrointestinal tract and adheres to the intestinal mucosa. Preclinical research has also identified anti-inflammatory effects, including reductions in pro-inflammatory cytokines such as IL-6, IL-8, and IL-12.
In addition, LP299V supports intestinal barrier function by stimulating mucin production. This protective layer lines the gut and assists in maintaining healthy intestinal permeability. LP299V furthermore contributes to microbiome balance through competitive exclusion of undesirable microorganisms and the production of beneficial metabolites, including short-chain fatty acids, which play an important role in most bodily functions.
Selecting the right probiotic strain requires confidence in both scientific evidence and commercial performance. LP299V combines decades of clinical documentation with formulation flexibility, assisting brands in developing differentiated products across multiple health categories, and is backed by credible science.
Supported by research across digestive health, iron absorption, metabolic health, sport recovery, active nutrition, and microbiome-related outcomes.
Suitable for a wide range of applications including capsules, tablets, sachets, functional foods, dairy products, and beverages.
Excellent stability of up to 24 months in a wide range of formats and applications.
Backed by Probi’s expertise in strain development, formulation, manufacturing, and commercialization.
The LP299V® booklet summarizes the comprehensive science supporting the bacterial strain Lactiplantibacillus plantarum 299v. An opportunity to truly get to know and understand the benefits and the extensive research.
The booklet gives an overview of the in vitro, animal, and clinical studies with LP299V. It covers the knowledge on how this strain acts, the binding mechanism, the effects on the gut epithelium and mucosa production.
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Explore the latest research, formulation expertise, scientific publications and industry perspectives featuring LP299V.
Stay up to date with advanced probiotics and microbiome science, emerging research on probiotic strains for gut health and new findings related to LP299V.