Probi® has spent more than thirty years investigating the safety and efficacy of our probiotic strains. We conduct state-of-the-art preclinical and clinical studies, to evaluate the health effects and underlying mechanisms of our probiotics. Our scientists, and research groups around the globe, have published more than 60 human clinical trials on the LP299V® strain alone, primarily in the fields of digestive health and iron absorption.
Other strains have proven effective in other areas, such as immune health and bone health.
Beneath we present a few of our studies in selected areas.
TITLE: Treatment of IBS with Lactobacillus plantarum 299v: Therapeutic success increases with length of treatment – real-life data of a non-interventional study in Germany
AUTHORS: Krammer H, Storr M, Madisch A, Riffel J
PUBLICATION: Z Gastroenterol 2021; 59(02): 125-134
Please note that the publication is only available in German, but with an abstract in English
TITLE: Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome.
AUTHORS: Ducrotté P, Sawant P, Jayanthi V.
PUBLICATION: World J Gastroenterol. 2012;18(30):4012-8.
TITLE: A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome
AUTHORS: Niedzielin K, Kordecki H, Birkenfeld B
PUBLICATION: Eur J Gastroenterol Hepatol. 2001;13(10):1143-7.
TITLE: Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome
AUTHORS: Nobaek S, Johansson M L, Molin G, Ahrné S, Jeppsson B
PUBLICATION: Am J Gastroenterol. 2000;95(5):1231-8.
TITLE: Survival of Lactobacillus plantarum DSM 9843 (299v), and effect on the short-chain fatty acid content of faeces after ingestion of a rose-hip drink with fermented oats
AUTHORS: Johansson M L, Nobaek S, Berggren A, Nyman M, Björck I, Ahrné S, Jeppsson B, Molin G
PUBLICATION: Int J Food Microbiol. 1998;42(1-2):29-38.
TITLE: Differential effect on cell-mediated immunity in human volunteers after intake of different lactobacilli
AUTHORS: Rask C, Adlerberth I, Berggren A, Ahrén I L, Wold A E
PUBLICATION: Clin Exp Immunol. 2013;172(2):321-32.
TITLE: Randomised, double-blind and placebo-controlled study using new probiotic lactobacilli for strengthening the body immune defence against viral infections
AUTHORS: Berggren A, Lazou Ahrén I, Larsson N, Önning G
PUBLICATION: Eur J Nutr. 2011;50(3):203-10.
TITLE: Randomized, double blind and placebo controlled study using a combination of two probiotic lactobacilli to alleviate symptoms and frequency of common cold
AUTHORS: Busch R, Gruenwald J, Dudek S
PUBLICATION: Food Nutr Sci. 2013;4:13-20.
TITLE: Evaluation of the efficacy of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 on aspects of common cold infections in children attending day care: a randomised, double-blind, placebo-controlled clinical study.
AUTHORS: Lazou Ahrén I, Berggren A, Teixeira C, Martinsson Niskanen T, Larsson N.
PUBLICATION: Eur J Nutr. 2020 Feb;59(1):409-417.
TITLE: The effect of Lactiplantibacillus plantarum 299v together with a low dose of iron on iron status in healthy pregnant women: A randomized clinical trial
AUTHORS: Axling U, Önning G, Martinsson Niskanen T, Larsson N, Hansson S R, Hulthén L
PUBLICATION: Acta Obstet Gynecol Scand. 2021 Apr 21. (epub ahead of print)
TITLE: A lactic acid-fermented oat gruel increases non-haem iron absorption from a phytate-rich meal in healthy women of childbearing age
AUTHORS: Bering S, Suchdev S, Sjoltov L, Berggren A, Tetens I, Bukhave K
PUBLICATION: Br J Nutr. 2006;96(1):80-5.
TITLE: Probiotic strain Lactobacillus plantarum 299v increases iron absorption from an iron-supplemented fruit drink: a double-isotope cross-over single-blind study in women of reproductive age
AUTHORS: Hoppe M, Önning G, Berggren A, Hulthén L
PUBLICATION: Br J Nutr. 2015; 114(8): 1195–1202.
TITLE: Freeze-dried Lactobacillus plantarum 299v increases iron absorption in young females—Double isotope sequential single-blind studies in menstruating women
AUTHORS: Hoppe M, Önning G, Hulthén L
PUBLICATION: PLoS One. 2017; 12(12): e0189141.
TITLE: The Effect of Lactobacillus plantarum 299v on Iron Status and Physical Performance in Female Iron-Deficient Athletes: A Randomized Controlled Trial.
AUTHORS: Axling U, Önning G, Combs MA, Bogale A, Högström M, Svensson M.
PUBLICATION: Nutrients. 2020;12(5):1279.
TITLE: A probiotic mix partially protects against castration-induced bone loss in male mice
AUTHORS: Lina Lawenius, Hannah Colldén, Karin L Gustafsson, Jianyao Wu, Louise Grahnemo, Liesbeth Vandenput, Claes Ohlsson, Klara Sjögren
PUBLICATION: J Endocrinol 2022;254(2):91-101.
TITLE: Mild stimulatory effect of a probiotic mix on bone mass when treatment is initiated 1.5 weeks after ovariectomy in mice
AUTHORS: Claes Ohlsson, Lina Lawenius, Annica Andersson, Karin Gustafsson, Jianyao Wu, Marie Lagerquist, Sofia Movérare-Skrtic, Ulrika Islander, Klara Sjögren
PUBLICATION: Am J Physiol Endocrinol Metab. 2021;320(3):E591-E597
TITLE: A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells
AUTHORS: Lavasani S, Dzhambazov B, Nouri M, Fåk F, Buske S, Molin G, Thorlacius H, Alenfall J, Jeppsson B, Weström B
PUBLICATION: PLoS One. 2010;5(2):e9009.
TITLE: Probiotics protect mice from ovariectomy-induced cortical bone loss
AUTHORS: Ohlsson C, Engdahl C, Fåk F, Andersson A, Windahl S H, Farman H H, Movérare-Skrtic S, Islander U, Sjögren K
PUBLICATION: PLoS One. 2014;9(3):e92368.
TITLE: Probiotic treatment using a mix of three Lactobacillus strains for lumbar spine bone loss in postmenopausal women: a randomised, double-blind, placebo-controlled, multicentre trial
AUTHORS: Jansson P-A, Curiac D, Lazou Ahrén I, Hansson F, Martinsson Niskanen T, Sjögren K, Ohlsson C
PUBLICATION: The Lancet Rheumatology 2019;1(3):e154-e162.
Effect of Probiotic Streptococcus salivarius K12 and M18 Lozenges on the Cariogram Parameters of Patients With High Caries Risk: A Randomised Control Trial
AUTHORS: Saravanan Poorni, M S Nivedhitha, Manali Srinivasan, Arthi Balasubramaniam
Does Streptococcus Salivarius Strain M18 Assumption Make Black Stains Disappear in Children?
AUTHORS: Elena Bardellini, Francesca Amadori, Emanuela Gobbi, Anna Ferri, Giulio Conti, Alessandra Majorana
Use of Streptococcus salivarius K12 to reduce the incidence of pharyngo-tonsillitis and acute otitis media in children: a retrospective analysis in not-recurrent pediatric subjects
AUTHORS: Francesco Di Pierro, Paolo Risso, Elena Poggi, Anna Timitilli, Sara Bolloli, Maurizio Bruno, Egidio Caneva, Riccardo Campus, Alessandro Giannattasio
Clinical evaluation of the oral probiotic Streptococcus salivarius K12 in the prevention of recurrent pharyngitis and/or tonsillitis caused by Streptococcus pyogenes in adults
AUTHORS: Francesco Di Pierro, Teresa Adami, Giuliana Rapacioli, Nadia Giardini, Christian Streitberger
Cardiometabolic benefits of Lacticaseibacillus paracasei 8700:2: A randomized double-blind placebo-controlled trial
Authors: Jialu Yang, Jingyi Huang, Zhihao Huang, Yingxi Xu, Wenkang Li, Shanshan Zhu, Yawen Zhao, Bingqi Ye, Ludi Liu, Jiangyuan Zhu, Min Xia, Yan Liu
Intake of Lactiplantibacillus plantarum HEAL9 Improves Cognition in Moderately Stressed Subjects: A Randomized Controlled Study
AUTHORS: Gunilla Önning,Caroline Montelius, Magnus Hillman, and Niklas Larsson
Publication: Nutrients (2023) 15 (15), 3466
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