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Probi® has spent more than thirty years investigating the safety and efficacy of our probiotic strains. We conduct state-of-the-art preclinical and clinical studies, to evaluate the health effects and underlying mechanisms of our probiotics. Our scientists, and research groups around the globe, have published more than 60 human clinical trials on the LP299V® strain alone, primarily in the fields of digestive health and iron absorption.
Other strains have proven effective in other areas, such as immune health and bone health.
Beneath we present a few of our studies in selected areas.
TITLE: Clinical trial: Lactobacillus plantarum 299v
TITLE: A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome
AUTHORS: Niedzielin K, Kordecki H, Birkenfeld B
PUBLICATION: Eur J Gastroenterol Hepatol. 2001;13(10):1143-7.
TITLE: Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome
AUTHORS: Nobaek S, Johansson M L, Molin G, Ahrné S, Jeppsson B
PUBLICATION: Am J Gastroenterol. 2000;95(5):1231-8.
TITLE: Survival of Lactobacillus plantarum DSM 9843 (299v), and effect on the short-chain fatty acid content of faeces after ingestion of a rose-hip drink with fermented oats
AUTHORS: Johansson M L, Nobaek S, Berggren A, Nyman M, Björck I, Ahrné S, Jeppsson B, Molin G
PUBLICATION: Int J Food Microbiol. 1998;42(1-2):29-38.
TITLE: Differential effect on cell-mediated immunity in human volunteers after intake of different lactobacilli
AUTHORS: Rask C, Adlerberth I, Berggren A, Ahrén I L, Wold A E
PUBLICATION: Clin Exp Immunol. 2013;172(2):321-32.
TITLE: Randomised, double-blind and placebo-controlled study using new probiotic lactobacilli for strengthening the body immune defence against viral infections
AUTHORS: Berggren A, Lazou Ahrén I, Larsson N, Önning G
PUBLICATION: Eur J Nutr. 2011;50(3):203-10.
TITLE: Randomized, double blind and placebo controlled study using a combination of two probiotic lactobacilli to alleviate symptoms and frequency of common cold
AUTHORS: Busch R, Gruenwald J, Dudek S
PUBLICATION: Food Nutr Sci. 2013;4:13-20.
TITLE: Evaluation of the efficacy of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 on aspects of common cold infections in children attending day care: a randomised, double-blind, placebo-controlled clinical study.
AUTHORS: Lazou Ahrén I, Berggren A, Teixeira C, Martinsson Niskanen T, Larsson N.
PUBLICATION: Eur J Nutr. 2020 Feb;59(1):409-417.
TITLE: A lactic acid-fermented oat gruel increases non-haem iron absorption from a phytate-rich meal in healthy women of childbearing age
AUTHORS: Bering S, Suchdev S, Sjoltov L, Berggren A, Tetens I, Bukhave K
PUBLICATION: Br J Nutr. 2006;96(1):80-5.
TITLE: Probiotic strain Lactobacillus plantarum 299v increases iron absorption from an iron-supplemented fruit drink: a double-isotope cross-over single-blind study in women of reproductive age
AUTHORS: Hoppe M, Önning G, Berggren A, Hulthén L
PUBLICATION: Br J Nutr. 2015; 114(8): 1195–1202.
TITLE: Freeze-dried Lactobacillus plantarum 299v increases iron absorption in young females—Double isotope sequential single-blind studies in menstruating women
AUTHORS: Hoppe M, Önning G, Hulthén L
PUBLICATION: PLoS One. 2017; 12(12): e0189141.
TITLE: The Effect of Lactobacillus plantarum 299v on Iron Status and Physical Performance in Female Iron-Deficient Athletes: A Randomized Controlled Trial.
AUTHORS: Axling U, Önning G, Combs MA, Bogale A, Högström M, Svensson M.
PUBLICATION: Nutrients. 2020;12(5):1279.
TITLE: A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells
AUTHORS: Lavasani S, Dzhambazov B, Nouri M, Fåk F, Buske S, Molin G, Thorlacius H, Alenfall J, Jeppsson B, Weström B
PUBLICATION: PLoS One. 2010;5(2):e9009.
TITLE: Probiotics protect mice from ovariectomy-induced cortical bone loss
AUTHORS: Ohlsson C, Engdahl C, Fåk F, Andersson A, Windahl S H, Farman H H, Movérare-Skrtic S, Islander U, Sjögren K
PUBLICATION: PLoS One. 2014;9(3):e92368.
TITLE: Probiotic treatment using a mix of three Lactobacillus strains for lumbar spine bone loss in postmenopausal women: a randomised, double-blind, placebo-controlled, multicentre trial
AUTHORS: Jansson P-A, Curiac D, Lazou Ahrén I, Hansson F, Martinsson Niskanen T, Sjögren K, Ohlsson C
PUBLICATION: The Lancet Rheumatology 2019;1(3):e154-e162.
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