Probi’s newest offering, a novel postbiotic solution is designed to deliver targeted gut and immune support with superior stability across modern food and beverage applications and complex supplement formulations.

Formulate for a future of gut & immune health
Today’s consumers are actively seeking science-backed solutions that support everyday health, especially for gut health and immunity.

Brands and manufacturers face real formulation challenges with live probiotics:

         -    Stability across the shelf life
         -    Sensitivity to heat and processing
         -    Cold chain requirements

Rham271h solves these challenges without compromising functionality.

What are postbiotics?
Postbiotics are a preparation of inanimate microorganisms and/or they components that confers a health benefit on the host.

That means they consist of non-living microbial cells or cell fragments that are:

        -    Heat treated 
        -    Sometimes accompanied by their metabolites
        -    No longer capable of colognizing
        -    Biologically active in ways that support health  

The result?

• Targeted and consistent functionality
• High stability in a wide range of applications
• Significant flexibility in formulation

Why Choose Rham271h?
Built on decades of microbiome expertise, Rham271h is the postbiotic version of Lacticaseibacillus rhamnosus 271 (DSM 6594) developed to unlock new opportunities in functional nutrition.

Formulate without compromise

• No cold chain or viability considerations
• Stable throughout shelf life and processing
• Compatible with diverse ingredients and formats
• Enables applications where probiotics present challenges

Designed for modern consumers

• Supports everyday gut and immune health
• Meets growing demand for health-focused food and beverages
• Neutral taste, texture, and appearance
• Suitable for daily consumption
• Clean-label friendly

Rham271h is derived from the well-characterized probiotic strain Lacticaseibacillus rhamnosus 271 (DMS 6594). The heat-killed strain retains biological activity while offering enhanced stability to pH, heat, and shelf conditions, with documented effects on microbiota composition and immune function.

• The probiotic version (Rham271™) has demonstrated the ability to support microbial balance and immune-related outcomes
• In vitro studies show that Rham271h retains key bioactive properties, including the ability to modulate immune markers in its postbiotic form

Promotes key pathways
Rham271h postbiotic interacts with the body via well-defined biological mechanisms:

• Helps maintain immunity and gut barrier integrity/function
• Modulates immune responses, supporting balance and resilience

Supports innovation across formats
Rham271h enables stable, scalable solutions across a wide range of functional applications:

A growing opportunity
Demand for gut and immune health continues to rise globally:

Postbiotics are emerging as a fast-growing category, offering scientific credibility combined with formulation flexibility for next-generation products.

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