Press Release - 21 Mar 2024

New study showing true synergistic benefits of Clasado's and Probi®'s synbiotic concept

A study recently published highlights the findings from the combination of the two proprietary and well-documented ingredients Bimuno ® GOS and Probi Defendum ® which shown to significantly increase the production of lactate and short-chain fatty acids, specifically butyrate.  

There is a rising interest and awareness in health and nutrition, and consumers seek ways to improve their digestive, immune, and overall health. Following probiotic supplements, synbiotic supplements (comprising of 2,900 products on the market today) remain the most developed category. Synbiotics challenges pure probiotics by volume of consumers online engagement which showed a growth of 16% in the first half of 2023. As such, synbiotics supplements have overtaken (pure) probiotic supplements of online engagement in first half of 2023.1 The global synbiotic products market is predicted to continuously grow with a CAGR rate of 7.5% between 2023 to 2030.2 


The recently published study shows the superior benefit of combining Clasado’s Bimuno GOS with Probi’s immune strengthening concept, Probi Defendum. The results showed that the probiotic strains L. plantarum HEAL9 (HEAL9™) and L. paracasei 8700:2® were able to utilize the Bimuno GOS for growth, resulting in increased levels of lactate and butyric acid, two well-known health-promoting compounds. This indicates a synergistic synbiotic relationship between these prebiotic and probiotic ingredients. The study also evaluated the combination of Bimuno GOS and Probi´s gut health promoting concept Probi Digestis® which are shown to act as complementary synbiotics, meaning both ingredients are effective and promote their individual health benefits without interaction. This study is thereby one of few scientific studies clearly showing that the combination of probiotics and prebiotics can have a greater benefit than either ingredient alone.


"With our strong foundation in probiotics for gut and immune health, we are happy to demonstrate that we together with our partner Clasado can deliver proven synbiotic solutions with enhanced health benefits. This strengthens our already existing offers, Probi Digestis and Probi Defendum, and broadens our offerings in the biotics area”, says Anita Johansen, CEO Probi AB. 


The study “A Novel Synbiotic Blend of Galactooligosaccharide (GOS) and a Two-Strain Probiotic Acts Synergistically to Increase Lactate and Short-Chain Fatty Acid Production in a Short-Term Ex Vivo Colon Fermentation Model” was published in International Journal of Nutritional Sciences (2024) 9 (1), and can be found here: LINK


1 Lumina Intelligence (October 2023): Biotics H1 2023 Key Findings 

2 FMI Synbiotics products market size June 2022 

3 International Scientific Association for Probiotics and Prebiotics (ISAPP)


For further information, please contact: 

Anita Johansen, CEO, Probi AB, Phone: +46 46 286 89 48, 

Christina Vegge, Sr Director R&D, Probi AB, Phone: +46 46 286 89 81, E-mail:



Synbiotic Fast Facts 


Synbiotics are defined as “a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host”.3 Furthermore, a synbiotic solution can be either synergistic or complementary. A synergistic synbiotic is a solution where “the substrate is designed to be selectively utilized by the co-administered microorganism(s)3. In this case the solution is composed of a prebiotic and a probiotic that selectively nourish each other. This results in enhanced health benefits in the host from the combined solution, versus what would be achieved by one of the ingredients alone. “A complementary synbiotic is a synbiotic composed of a probiotic combined with a prebiotic, which is designed to target autochthonous microorganisms”.3 In this case, this is defined as a prebiotic and probiotic working side by side, each of them delivering their proposed health benefit to the host. According to the definitions by ISAPP3 it is required that both the prebiotic and the probiotic must meet the minimal requirements defined for each component.  


Ingredients Fast Facts   













Probi® is a global company focused exclusively on researching, manufacturing, and delivering probiotics for supplements and functional food. We are experts at managing stable, live bacteria from R&D through every stage of the manufacturing process and are dedicated to making the health-enhancing benefits of probiotics available to people everywhere. Our health concepts, formulations, and formats are supported by robust clinical documentation. Since our founding in 1991 at Sweden’s Lund University, Probi has expanded its operations to more than 40 markets. We hold more than 400 patents globally. Probi had sales of 628 MSEK in 2023. Probi's shares are listed on Nasdaq Stockholm, Mid-cap, and there were around 3,400 shareholders on December 31, 2023.